What's included?

10% Capacity Uplift and 20% Less Variability in Chromatography Purification
Life Sciences

10% Capacity Uplift and 20% Less Variability in Chromatography Purification

Explore the Results

See how Quartic MVDA enabled real-time purification insight and yield uplift

Key Results Delivered

0 %

increase in production capacity

0 %

reduction in batch yield variability

0 –20%

Increase in individual Batch Yields

$ 0 Mn/year

Gains by Eliminating failed batches

About The Client

A global pharmaceutical leader specializing in diabetes and chronic care therapeutics. This client operates high-volume purification processes across multiple biologics manufacturing sites and was seeking greater consistency and productivity in batch chromatography.
Company

Industry:

Life Sciences

Location:

Europe

The Purification Challenge

Chromatography degradation introduced inconsistencies in purification yield. Failures weren’t detected until after batch completion, requiring SME review and rework. These issues delayed corrective actions and impacted throughput.

Yield impacted by inconsistent chromatography degradation

Detection delays for load mixing and packing issues

SME dependency delayed failure investigation

High-cost rework of low-yield batches

Our Solution

Quartic integrated equipment and batch data to deliver contextual insights in real time. Using MVDA, high-performing batch trajectories were modeled as “golden batches,” enabling instant deviation alerts and root cause detection — empowering teams to intervene mid-process. The approach helped drive chromatography purification optimization at scale by identifying process shifts that impacted chromatography yield improvement and minimizing batch yield variability.

Solutions We Have Provided

  • Built golden batch MVDA profiles from historical data
  • Real-time deviation detection and root cause tagging
  • Enabled SME-free identification of low-yield patterns
Solution Dashboard

Results & Benefits - Consistent Yield and Faster Batch Turnaround

The client improved batch yields by up to 20% and raised production capacity by 10% — without equipment upgrades. Analytics-based repacking and early deviation alerts helped prevent low-yield runs, reducing rework and increasing profitability.

This enabled continuous chromatography yield improvement while reducing batch yield variability and ensuring consistent chromatography purification optimization.

Results

Quartic Platform Capabilities Used

iLuminator Icon

iLuminator

Created real-time context across purification units and batch data.

iLuminator Screenshot
Batch MVDA Icon

Batch MVDA

Generated golden batch profiles and enabled deviation-based failure detection.

Batch MVDA Screenshot

Quartic MVDA helped us identify deviations early, prevent failures, and boost yield consistency across chromatography purification.

Senior Director Manufacturing Science Global Pharma Company

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