Automated PAT for Offline, In-line and Predictive Analysis

As we develop and manufacture increasingly complex chemical, biological or bio-chemical products, the use of PAT (Process Analytical Technology) such as RAMAN spectroscopy and near-infrared spectroscopy becomes indispensable – for product development, critical process and quality parameter monitoring during manufacturing steps or final quality monitoring.

While PAT instruments are becoming more prevalent, the cost and effort required to do assays for the components of interest or impurities impedes widespread use to realize the full potential of investment in these technologies.

Using automation with Machine Learning, the Quartic PAT application allows offline assays to be automated; creates multiple soft sensors for process and quality parameters of interest that can be used for in-line real-time or near real-time monitoring, and allows closed loop control of unit operations using PAT.

Users can also take the next step of building process and product profile prediction during manufacturing by combining PAT data with other process parameters.